The goal of every individual in the workplace or job is to generate profit in life, even sometimes at the stake of violating ethics. Compliance is how to follow the rules while working in the healthcare industry. The Physicians should have compliance knowledge to ensure the business’s success and ethical business practices. Compliance ensures that all working methods rule CPT, HIPAA, and CMS. Physicians intend to follow these rules in the healthcare industry to benefit businesses and physicians. Under current circumstances, the role of healthcare laws and regulations cannot be denied to avoid the risk of billing and claim denials. Physicians must be aware of the four common compliance mistakes to pursue a successful and smooth healthcare practice in the contemporary and dynamic healthcare system. The article will not only discuss these four common compliance mistakes but also share actions that help to avoid these common compliance mistakes.